Deleta Tablet

✔️ Uses of Deleta Tablet

• Treatment of Depression

✔️ How does Deleta Tablet work?

Deleta Tablet is an antipsychotic medicine that is used as a long-acting drug for schizophrenia and also as an antidepressant. It belongs to a class of thioxanthene drug that works by blocking the dopamine D1 and D2 receptors thereby increasing serotonin and noradrenaline.

✔️ Side Effects of Deleta Tablet

• Weight Gain
• Constipation
• Dry Mouth
• Excessive Salivation
• Sleepiness
• Orthostatic Hypotension
• Muscle Rigidity
• Tremor
• Restlessness

✔️ Quick Suggestions:

• Deleta Tablet helps treat anxiety and depression.
• Use caution while driving or doing anything that requires concentration as Deleta Tablet can cause dizziness and sleepiness.
• Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.
• It can cause changes in your blood sugar levels. Monitor your blood sugar regularly.
• Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, or a urinary disorder.
• Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
• Let your doctor know you are taking Deleta Tablet before undergoing any surgical procedure.

✔️ Indication of Deleta Tablet

Deleta Tablet is a combination of [Flupenthixol (0.5 mg) + Melitracen (10 mg)] of medicine used for the treatment of depression.

✔️ Pharmacology

Flupentixol: Flupentixol is a neuroleptic medication that also exhibits anxiolytic and antidepressant properties when administered in small doses.

Melitracen: Melitracen is a bipolar thymoleptic medication that shows activating properties in low doses.

Combination Effect: The combination of flupentixol and melitracen in Deleta Tablet 10's results in preparation with antidepressant, anxiolytic, and activating properties.

Maximal Serum Concentration: After oral administration of Deleta Tablet, the maximal serum concentration of flupentixol is reached in about 4 hours, as is the case with melitracen.

Biological Half-life: The biological half-life of flupentixol is approximately 35 hours, while that of melitracen is about 19 hours.

Pharmacokinetic Properties: The combination of flupentixol and melitracen does not appear to influence the pharmacokinetic properties of the individual compounds. This means that the absorption, distribution, metabolism, and elimination of flupentixol and melitracen remain unaffected when they are used together.

The combination of flupentixol and melitracen in Deleta Tablet 10's provides a synergistic effect to effectively address depression, anxiety, and related symptoms. It's essential for patients to take the medication as prescribed by their doctor and report any side effects or concerns during the treatment. As with any medication, individual responses may vary, and regular follow-ups with the healthcare provider are essential to monitor the treatment's effectiveness and safety.

✔️ Dosage & Administration of Deleta Tablet

Adult Dosing:

• Usually, the recommended dose for adults is 2 tablets orally daily, to be taken in the morning and noon.
• In severe cases, the morning dose may be increased to 2 tablets.

Elderly Patients:

• Elderly patients should take 1 tablet in the morning.

Maintenance Dose:

• After the acute phase, the maintenance dose is typically 1 tablet orally in the morning.

Additional Sedative Treatment:

• In cases of insomnia or severe restlessness during the acute phase, additional treatment with a sedative is recommended.

Administration:

• Take Deleta Tablet 10's as advised by your doctor.
• Swallow the medicine with a glass of water.
• Do not crush or chew the medicine.

Individualized Treatment:

• The correct dose and duration of treatment will be determined by your doctor based on factors such as age, disease condition, and body weight.

Following these dosing instructions and adhering to the prescribed treatment plan is essential for the safe and effective use of Deleta Tablet 10's in the management of depression and related conditions. Patients should maintain regular communication with their healthcare provider and report any concerns or side effects during the treatment period. It's crucial to use the medication as prescribed to achieve the best treatment outcomes.

✔️ Interaction

Drug-Drug Interactions:

1. MAO Inhibitors: Deleta Tablet 10's may interact with MAO inhibitors (isocarboxazid, phenelzine), which are used to treat depression. Concurrent use should be avoided to prevent adverse effects.
2. Barbiturates: Concurrent use of Deleta Tablet 10's with barbiturates (pentobarbital, phenobarbital) should be avoided due to possible interactions.
3. CNS Depressants: Deleta tablets may interact with central nervous system (CNS) depressants (diazepam, clonazepam, alprazolam), leading to increased sedation and respiratory depression.
4. Neuroleptics: Concurrent use of Deleta Tablet 10's with neuroleptics (thioridazine, chlorpromazine) should be avoided due to potential interactions.

Drug-Food Interactions:

• Alcohol: Limit or avoid the consumption of alcohol while taking Deleta Tablet 10's as it may enhance drowsiness and central nervous system effects.

Drug-Disease Interactions: Deleta Tablet 10's should not be used in patients with the following conditions:

1. Circulatory Collapse: Specific failure of blood circulation.
2. Depressed Level of Consciousness: Patients with decreased consciousness.
3. Untreated Narrow-Angle Glaucoma: A type of eye condition.
4. Coma: Patients in a comatose state.
5. Blood Disorders: Patients with specific blood disorders.
6. Phaeochromocytoma: A small vascular tumor.
7. Recent Myocardial Infarction: Recent heart attack.
8. Atrioventricular Block or Disorders of Cardiac Rhythm: Certain heart rhythm abnormalities.
9. Coronary Artery Insufficiency: Inadequate blood supply to the heart.

Patients with any of these conditions should avoid Deleta Tablet 10's, and alternative treatments should be considered by their healthcare provider.

✔️ Contraindications

• Hypersensitivity: Patients who are hypersensitive or allergic to the components of Deleta Tablet 10's should not take this medication.
• Circulatory Collapse: Deleta Tablet 10's should not be used in patients with circulatory collapse, a severe condition of low blood pressure and poor blood flow.
• Decreased Level of Consciousness/Coma: Patients with decreased consciousness or in a coma should refrain from using Deleta Tablet 10's.
• Electroconvulsive Therapy (ECT) or Severe Depression Requiring Hospitalization: Deleta Tablet 10's is not recommended for use in patients undergoing electroconvulsive therapy or those with severe depression requiring hospitalization.
• Manic or Excited States: The medication should be avoided in patients with manic or excited states, as it may not be suitable for these conditions.
• Porphyrias: Patients with porphyrias, a group of blood disorders that involve the accumulation of specific proteins, should not take Deleta Tablet 10's.
• Epilepsy: Deleta Tablet 10's is not recommended for patients with epilepsy, a neurological disorder characterized by recurrent seizures.
• Prolactin Dependent Tumors or Breast Cancer: The medication should be avoided in patients with prolactin-dependent tumors or breast cancer.
• Parkinson's Disease: Deleta Tablet 10's should not be used in patients with Parkinson's disease, a progressive neurological disorder affecting movement and coordination.
• Narrow-Angle Glaucoma: Patients with narrow-angle glaucoma, a type of eye condition, should refrain from using Deleta Tablet 10's.
• Prostate Enlargement: The medication is not recommended for patients with prostate enlargement.
• Thyroid Disorders: Patients with thyroid disorders should not use Deleta Tablet 10's.
• Cardiac Disease or Arrhythmias: Deleta Tablet 10's should be avoided in patients with cardiac disease or irregular heart rhythms (arrhythmias).
• Severe Respiratory Disease: Patients with severe respiratory diseases should not take Deleta Tablet 10's.
• Kidney Failure: The medication is contraindicated in patients with kidney failure.
• Myasthenia Gravis: Deleta Tablet 10's is not recommended for patients with myasthenia gravis, a neuromuscular disorder.
• Pheochromocytoma: Patients with pheochromocytoma, a tumor of the adrenal glands, should refrain from using Deleta Tablet 10's.

✔️ Pregnancy & Lactation

This tablet should preferably not be given during pregnancy and lactation.

✔️ Precautions & Warnings

• Allergy: Do not use Deleta Tablet 10's if you are allergic to any of its components.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding before using Deleta Tablet 10's.
• Circulatory Collapse: The medication is contraindicated in patients with circulatory collapse, which refers to a specific failure of blood circulation.
• Depressed Level of Consciousness: Patients with depressed levels of consciousness due to any cause, such as intoxication with alcohol, opiates, or barbiturates, should not take Deleta Tablet 10's.
• Narrow-Angle Glaucoma: Deleta Tablet 10's should not be used in patients with untreated narrow-angle glaucoma, a type of eye condition.
• Coma: Patients in a comatose state should refrain from using Deleta Tablet 10's.
• Blood Disorders: The medication is contraindicated in patients with specific blood disorders.
• Phaeochromocytoma: Deleta Tablet 10's should not be used in patients with phaeochromocytoma, a small vascular tumor.
• Recent Myocardial Infarction: Patients with recent heart attacks (myocardial infarction) should avoid Deleta Tablet 10's.
• Atrioventricular Block or Disorders of Cardiac Rhythm: The medication is not recommended for patients with any degree of atrioventricular block or disorders of cardiac rhythm.
• Coronary Artery Insufficiency: Deleta Tablet 10's should be avoided in patients with coronary artery insufficiency, which involves inadequate blood supply to the heart.
• MAOIs: Concomitant treatment of Deleta Tablet 10's with MAOIs (monoamine oxidase inhibitors) is contraindicated as it may cause serotonin syndrome, a potentially serious condition with various symptoms.

✔️ Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children.